T cells from patients with Parkinson’s disease recognize α-synuclein peptides

Autor:	Francesca Garretti, John Pham, Xiaobo Mao, Julian Agin-Liebes, Ted M. Dawson, Simon Mallal, Curtis McMurtrey, Chelsea Carpenter, Ellen Kanter, April Frazier, John Sidney, Myles B.C. Dillon, Elizabeth J. Phillips, Bjoern Peters, Alessandro Sette, Christopher Liong, Lucien J. Cote, Roy N. Alcalay, Daniela Weiskopf, Carla Oseroff, Cecilia S. Lindestam Arlehamn, William H. Hildebrand, David Sulzer, Valina L. Dawson
Rok vydání:	2017
Předmět:	0301 basic medicine Multidisciplinary Parkinson's disease biology Major histocompatibility complex medicine.disease medicine.disease_cause Epitope nervous system diseases 3. Good health Autoimmunity 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Neuroimmunology Antigen Immunology biology.protein medicine Cytotoxic T cell Allele 030217 neurology & neurosurgery
Zdroj:	Nature. 546:656-661
ISSN:	1476-4687 0028-0836
DOI:	10.1038/nature22815
Popis:	Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson's disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the association of Parkinson's disease with specific major histocompatibility complex alleles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::790b8c842ae14e7efdd60780531848a4 https://doi.org/10.1038/nature22815 Zobrazit plný text záznamu Full text from SpringerLink