p53 Oligomerization Domain Mutants: A New Class of Mutants That Retain 'License to Kill'

Autor:	David Stieg, Kaitlyn Casey, Maureen E. Murphy
Rok vydání:	2023
Předmět:	Oncology
Zdroj:	Cancer Discovery. 13:1046-1048
ISSN:	2159-8290 2159-8274
DOI:	10.1158/2159-8290.cd-23-0200
Popis:	Summary: In this issue of Cancer Discovery, companion articles from the Prives and Lozano groups describe functional analyses of a common dimeric mutant of p53 found in Li–Fraumeni disease and sporadic cancer: A347D (AD). The authors show that the AD mutant is completely defective for canonical p53 transcriptional function, but interestingly retains some tumor suppressor function, which they show is manifested as “neomorphic” activities in transcription and the control of mitochondrial metabolism. See related article by Gencel-Augusto et al., p. 1230 (7). See related article by Choe et al., p. 1250 (6).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7874e24ef8e2ef2041a43ad50826d5b6 https://doi.org/10.1158/2159-8290.cd-23-0200 Zobrazit plný text záznamu