A Visible Light Photoredox Catalysed Radical Pictet-Spengler Reaction

Autor:	Milena L. Czyz, Tyra H. Horngren, Mohammed A. M. Alhajji, Joshua Almond-Thynne, Anastasios Polyzos, Theerada Seehamongkol, Anthony J. Barrett
Rok vydání:	2020
Předmět:	chemistry.chemical_compound Reaction mechanism Pictet–Spengler reaction Biocatalysis Chemistry Tetrahydroisoquinoline Intramolecular force Regioselectivity Photoredox catalysis General Chemistry Photochemistry Catalysis
Zdroj:	Australian Journal of Chemistry. 73:189
ISSN:	0004-9425
DOI:	10.1071/ch19423
Popis:	A methodology for a radical Pictet–Spengler reaction promoted by visible light photoredox catalysis is described. This strategy furnishes tetrahydroisoquinoline derivatives bearing electron poor and electron rich substituents. The reaction proceeds at room temperature and with excellent regioselectivity for the 6-endo intramolecular cyclisation. This radical approach provides a complementary method for the synthesis of the tetrahydroisoquinoline scaffold with substitution patterns inaccessible via established thermal transformations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7867c8ff3771d509f1c345414dd9a40c https://doi.org/10.1071/ch19423 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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