Serum Metabolome of Coffee Consumption and its Association With Bone Mineral Density: The Hong Kong Osteoporosis Study
| Autor: | Yin-Pan Chau, Vincent Ka-Fai Cheng, Annie W.C. Kung, Chor-Wing Sing, Gloria H.Y. Li, Kathryn C.B. Tan, Ching-Lung Cheung, Philip Chun-Ming Au |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Metabolite Clinical Biochemistry Osteoporosis 030209 endocrinology & metabolism Coffee consumption Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Trigonelline Internal medicine medicine Metabolome 030212 general & internal medicine Femoral neck Bone mineral business.industry Biochemistry (medical) medicine.disease medicine.anatomical_structure chemistry business Caffeine |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 105:e619-e627 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/clinem/dgz210 |
| Popis: | Background Inconsistent associations between coffee consumption and bone mineral density (BMD) have been observed in epidemiological studies. Moreover, the relationship of bioactive components in coffee with BMD has not been studied. The aim of the current study is to identify coffee-associated metabolites and evaluate their association with BMD. Methods Two independent cohorts totaling 564 healthy community-dwelling adults from the Hong Kong Osteoporosis Study (HKOS) who visited in 2001–2010 (N = 329) and 2015–2016 (N = 235) were included. Coffee consumption was self-reported in an food frequency questionnaire. Untargeted metabolomic profiling on fasting serum samples was performed using liquid chromatography–mass spectrometry platforms. BMD at lumbar spine and femoral neck was measured by dual-energy X-ray absorptiometry. Multivariable linear regression and robust regression were used for the association analyses. Results 12 serum metabolites were positively correlated with coffee consumption after Bonferroni correction for multiple testing (P < 4.87 × 10–5), with quinate, 3-hydroxypyridine sulfate, and trigonelline (N’-methylnicotinate) showing the strongest association. Among these metabolites, 11 known metabolites were previously identified to be associated with coffee intake and 6 of them were related to caffeine metabolism. Habitual coffee intake was positively and significantly associated with BMD at the lumbar spine and femoral neck. The metabolite 5-acetylamino-6-formylamino-3-methyluracil (AFMU) (β = 0.012, SE = 0.005; P = 0.013) was significantly associated with BMD at the lumbar spine, whereas 3-hydroxyhippurate (β = 0.007, SE = 0.003, P = 0.027) and trigonelline (β = 0.007, SE = 0.004; P = 0.043) were significantly associated with BMD at the femoral neck. Conclusions 12 metabolites were significantly associated with coffee intake, including 6 caffeine metabolites. Three of them (AFMU, 3-hydroxyhippurate, and trigonelline) were further associated with BMD. These metabolites could be potential biomarkers of coffee consumption and affect bone health. |
| Databáze: | OpenAIRE |
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