Synthesis and DNA Interaction of Platinum Complex/Peptide Chimera as Potential Drug Candidates (Eur. J. Org. Chem. 32/2010)
| Autor: | Mariana S. Damian, Sofi K. C. Elmroth, Ulf Diederichsen, Hanna K. Hedman |
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| Rok vydání: | 2010 |
| Předmět: |
Cisplatin
chemistry.chemical_classification Stereochemistry Organic Chemistry chemistry.chemical_element Peptide 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Combinatorial chemistry 0104 chemical sciences Nucleobase chemistry.chemical_compound Chimera (genetics) chemistry Covalent bond medicine Molecule Physical and Theoretical Chemistry 0210 nano-technology Platinum DNA medicine.drug |
| Zdroj: | European Journal of Organic Chemistry. 2010 |
| ISSN: | 1434-193X |
| Popis: | The cover picture shows the covalent DNA binding of cisplatin-like complexes. These molecules were designed as hybrids between the platinum coordination site and positively charged peptides, which involves the covalent binding of one or two nucleobases by cisplatin-analogous platinum complexes and the bending of double-stranded DNA initiated by the peptide chain. An optimization of cisplatin-like anticancer drugs is intended. Binding of cisplatin analogs is facilitated by simultaneous DNA bending. Details are discussed in the article by U. Diederichsen et al. on p. 6161 ff. |
| Databáze: | OpenAIRE |
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