| Autor: |
Maryanne Romero, Choy Yoke Poon, Khee Chee Soo, Patricia S. P. Thong |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Oral Oncology. 49:S103-S104 |
| ISSN: |
1368-8375 |
| DOI: |
10.1016/j.oraloncology.2013.03.273 |
| Popis: |
Aim The 5-year survival rate for oral squamous cell carcinoma (OSCC) has remained low despite advances in treatment protocols due to late stage of presentation for most patients (stage III/IV). Biomarkers in the saliva may potentially solve this conundrum by allowing for early detection of cancer. The aim of this paper is to determine if biomarkers previously identified are able to distinguish cases of OSCC from their normal controls. We also aim to shed light on the protein signature of patients post-treatment for OSCC, and establish if it reverts back to levels in healthy controls. Material and methods This study explored the protein signature of five salivary proteins in a total of 101 subjects – patients with oral cancer, normal subjects, and patients post-treatment for OSCC. Unstimulated saliva was collected from all three groups, and protein levels quantified using ELISA. Logistic regression was applied and ROC curves conducted to evaluate the association between the biomarkers and OSCC. The same model was used to rank the biomarkers in terms of predictive value. Results Results demonstrated an increased expression of Catalase and CD59 ( p -value p -value Conclusion Catalase and CD59 may have potential as diagnostic markers for OSCC, and if future prospective studies show the same trend, it will pave the way for point-of-care diagnostics in clinics to aid in management of patients with oral lesions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect