Assessment of Protein C Levels in Patients with Ischaemic Stroke in South-South Nigeria: A Study of Cases in University of Benin Teaching Hospital, Benin City
| Autor: | Ugochukwu Uzodinma Nnadozie, Augustine Ejike Okoye, Oluomachi Charity Nnachi, Ogah Emeka Onwe, OA Awodu, Robert Azu Nnachi, Chukwuemeka Okorie Eze, Matilda Adesuwa Ojo |
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| Rok vydání: | 2019 |
| Předmět: |
030506 rehabilitation
medicine.medical_specialty Population Gastroenterology Protein S 03 medical and health sciences 0302 clinical medicine Protein C deficiency Internal medicine Medicine Thromboplastin Platelet education Stroke education.field_of_study biology business.industry General Medicine medicine.disease Coagulation biology.protein 0305 other medical science business 030217 neurology & neurosurgery Protein C medicine.drug |
| Zdroj: | Global Journal of Health Science. 11:106 |
| ISSN: | 1916-9744 1916-9736 |
| DOI: | 10.5539/gjhs.v11n14p106 |
| Popis: | Background/Objective: Protein C (PC) is a vitamin K – dependent coagulation inhibitor produced in the liver. Acting together with its cofactor, protein S (PS), activated PC inhibits activated factors V and VIII thus downregulating thrombin generation which may predispose to inappropriate clot formation. This study aimed to ascertain the role of protein C deficiency in the development of ischaemic stroke in order to establish its relevance in stroke management in our environment. Materials and Methods: Sixty-five ischaemic stroke patients and controls matched for age and sex were recruited in the study, blood samples were taken for haematological indices, prothrombin and activated partial thromboplastin times (PT and APTT) and protein C. Functional and qualitative assessments of protein C were done by chromogenic and immunoassay methods respectively. Data were analyzed with SPSS version 18. Results: A total of 130 subjects comprising 65 stroke subjects and 65 controls were recruited in the study. Mean age of the stroke group was 60.4±12.3yrs and the control is 59.0±14.1yrs. The mean difference in PC Ag level, PC Ag(%) and functional activity between the groups were not statistically significant (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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