Evidence of associations between bipolar disorder and the brain-derived neurotrophic factor (BDNF) gene

Autor:	Alison C. Fitches, Robin J. Olds, Catherine Sears, David Markie
Rok vydání:	2011
Předmět:	Brain-derived neurotrophic factor Genetics Linkage disequilibrium Single-nucleotide polymorphism medicine.disease Psychiatry and Mental health Polymorphism (computer science) medicine Bipolar disorder Psychology rs6265 Allele frequency Biological Psychiatry Genetic association
Zdroj:	Bipolar Disorders. 13:630-637
ISSN:	1398-5647
DOI:	10.1111/j.1399-5618.2011.00955.x
Popis:	Sears C, Markie D, Olds R, Fitches A. Evidence of associations between bipolar disorder and the brain-derived neurotropic factor (BDNF) gene. Bipolar Disord 2011: 13: 630–637. © 2011 The Authors. Journal compilation © 2011 John Wiley & Sons A/S. Objective: Brain-derived neurotrophic factor (BDNF) has important roles in neural cell growth and differentiation. Despite multiple lines of evidence suggesting BDNF as a possible contributor to the pathogenesis of bipolar disorder (BD), the results of genetic association studies have been mixed. We hypothesize that BDNF gene polymorphisms may confer increased susceptibility to BD. Methods: Using a cohort of multiplex bipolar families, we performed family-based association testing to look for associations between BD and eight single nucleotide polymorphisms (SNPs) from BDNF. Results: We found associations (p
Databáze:	OpenAIRE
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