Efficacy and Tolerability of Pregabalin vs Sertralin in Generalised Anxiety Disorder Concise Communication

Autor: Mina Cvjetković-Bošnjak
Rok vydání: 2016
Předmět:
Zdroj: Journal of Yoga & Physical Therapy.
ISSN: 2157-7595
Popis: Copyright: © 2015 Cvjetkovic-Bosnjak M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Generalised Anxiety Disorder(GAD) represent a chronic mental illness characterized with pathological fear,extremely persistant worry usually about minor everyday problems and with numerous of vegetative symptoms [1-17]. It represent difficult problem in Mental Health,as life occurance of GAD is 5-7% Symptoms of GAD, according to ICD-X and DSM-V even today can be misdiagnosed, and unadeqvatelly treated [8-24] . If the symptoms are long lasting and untreated, often comorbidity with depression,alcohol abuse,and high suicidality level make extremely serious mental problem [2-9]. GAD interfered significantly with everyday activities and causes substantional personall distres so proper diagnosis and adeqvate treatment have to become priority in medical practice. WFSBP (World Federation of Societes of Biological Psychiatry) recommend SSRI (Selective Serotonin Reutake Inhibitors), SNRI (Serotonin and Norepinefrin Reuptake Inhibiors) and pregabaline, atypical anxiolytc as first line treatment, in combination with psychotherapy [7-19]. In present study, efficacy and tolerability of pregabaline vs.sertraline in patient with diagnoses of GAD was observed.The study included 107 in-patients age 20-60,both gender. Duration of disorder was in average of 4,7+0,3 years in group of patients treated with sertraline and about 4,6+0,4 in group treated with pregabalin.In previous episodes, 98% of all included patients were treated with SSRI and SNRI, in adeqvately therapeutical doses. Actually, patients were admitted in daily treatment due to new episode of GAD. In included patients, washup period was one week. At the begining of the study, all patients were reqvired to have a Covi Anxiety Scale, total score >9 and total score on HAMA (Hamilton Anxiety Scale) >20.In first group, patients were treated with sertraline, (doses began from 50 mg up to mean value of 150 mg/die). Doses was titrated during one week.In second group patient were treated with pregabalin, doses at first day were 75 mg, and titrated to 225 mg/die during one week. In all included patients cognitive-behavioral therapy ,individual and group was performed, during investigation. The primary analysis was change in Hamilton Raiting Scale for Anxiety (HAMA), a total score from baseline to endpoint. Secondary indicator of efficacy was change in HAMA psychic (emotional) and somatic (physical) scores weekly till endpoint. Global clinical assessment was conducted by using the Clinical Global Impression change raiting (CGI).
Databáze: OpenAIRE
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