Reactions of neural elements of neocortex to action of hypoxia at the early neonatal period in rats

Autor:	Vladimir A. Otellin, L. I. Khozhai, T. T. Shishko
Rok vydání:	2014
Předmět:	Neocortex Physiology Endoplasmic reticulum Cellular differentiation Biology Hypoxia (medical) Golgi apparatus Biochemistry Cell biology symbols.namesake medicine.anatomical_structure Cytoplasm Neuropil medicine symbols Neuron medicine.symptom Neuroscience Ecology Evolution Behavior and Systematics
Zdroj:	Journal of Evolutionary Biochemistry and Physiology. 50:167-173
ISSN:	1608-3202 0022-0930
Popis:	We studied reactions of neural elements from different neocortex regions (sensorimotor, visual, auditory) to acute normobaric hypoxia on the model of human incomplete pregnancy (the 2-day-old rat pups) and revealed similar and unidirectional reorganization in all these regions. The chosen parameters of hypoxia induced the earliest detectable changes as fast as in a day since exposure: a decrease in cell body size and cytoplasmic volume, intensification of apoptotic cell death. By the end of the neonatal period (day 5), several ultrastructural changes were observed by indicating deceleration of processes of nerve cell differentiation: arrest of complication of smooth and rough endoplasmic reticulum and Golgi apparatus, the reduced number of free ribosomes and polysomes in cytoplasm as well as of axonal and dendritic growth cones in neuropil, delayed and disordered myelination of nerve fibers. All these morphofunctional abnormalities may be the structural basis for development of neonatal encephalopathies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::770c809ac6c76f54601174ff775d41f6 https://doi.org/10.1134/s0022093014020094 Zobrazit plný text záznamu Plný text ve formátu PDF