Bone mineral density and markers of bone turnover in young adult survivors of childhood lymphoblastic leukaemia
| Autor: | Jan C. Roos, G. Kardos, J. J. G. Hoorweg-Nijman, H.A. Delemarre-van de Waal, Corrie Popp-Snijders, C.M. Ridel, C. Netelenbos, J.J. van Dijk |
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| Rok vydání: | 1999 |
| Předmět: |
Bone mineral
Growth hormone activity medicine.medical_specialty Bone disease Bone density business.industry Endocrinology Diabetes and Metabolism Osteoporosis medicine.disease Bone resorption Bone remodeling Endocrinology medicine.anatomical_structure Internal medicine medicine business Femoral neck |
| Zdroj: | Clinical Endocrinology. 50:237-244 |
| ISSN: | 0300-0664 |
| Popis: | OBJECTIVE In order to determine if a serious disease like childhood acute lymphoblastic leukaemia (ALL) and the treatment necessary to cure the patients has long term effects on bone mass, we assessed bone mineral density (BMD) and several parameters involved in bone formation in a group of young adult survivors of ALL. DESIGN AND PATIENTS Fourteen male and ten female survivors, treated for ALL in childhood, were cross-sectionally studied, at a mean age of 25.1 years (range 20.1–34.9). All patients, except for two, had received cranial irradiation as part of their treatment (mean radiation dose 2460 cGy). MEASUREMENTS Height and weight were measured. Bone mineral density (BMD) was assessed using dual energy X-ray absorptiometry in the lumbar spine, femoral neck, femoral trochanter and at 1/3 distal and ultradistal in the radius. Early morning serum levels of LH, FSH, oestradiol or testosterone, IGF-1 and IGF-BP3 were determined as well as several specific markers of bone turnover. RESULTS Mean height, expressed as standard deviation score (SDS) was −1.12, significantly reduced. BMD in the lumbar spine, femoral neck and at 1/3 distal and ultradistal in the radius, was significantly lower compared to the reference population (P |
| Databáze: | OpenAIRE |
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