Prostaglandins, cyclic nucleotides, and adaptation of the heart to acute and chronic pressure overloading

Autor:	V. D. Pomoinetskii, V. M. Samfirova, N. G. Geling
Rok vydání:	1979
Předmět:	chemistry.chemical_classification medicine.medical_specialty Abdominal aorta General Medicine Rat heart General Biochemistry Genetics and Molecular Biology Muscle hypertrophy Endocrinology chemistry Rate of development medicine.artery Internal medicine medicine Nucleotide
Zdroj:	Bulletin of Experimental Biology and Medicine. 88:1248-1251
ISSN:	1573-8221 0007-4888
Popis:	The concentration of prostaglandins (PG) and cyclic nucleotides was determined in the rat heart at different times after coarctation of the abdominal aorta. The animals were divided into three types depending on the rate of development and degree of hypertrophy. Rats best adapted to pressure overloading of the heart (with the greatest degree of hypertrophy) had the highest PG level in the myocardium. Correlation was found between the increase in weight of the heart and the PGE/PGF2α ratio. A connection was demonstrated between PG and cyclic nucleotides in the myocardium in the course of its adaptation to pressure overloading. It is suggested that PG may be an important component of the system of adaptation of the heart to pressure overloading.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::76a03e8a56be24c3f7289d0ddf61bcd3 https://doi.org/10.1007/bf00835562 Zobrazit plný text záznamu Full text from SpringerLink