ChemInform Abstract: Further Novel Milbemycin Antibiotics from Streptomyces sp. E225: Fermentation, Isolation and Structure Elucidation

Autor:	S. A. Readshaw, Jeremy R. Everett, Christopher Reading, Roderick John Dorgan, Simon Edward Blanchflower, Geoffrey Harold Baker, Peter Robin Shelley, B. R. Manger
Rok vydání:	2010
Předmět:	biology Stereochemistry Chemical shift Substituent General Medicine Ring (chemistry) biology.organism_classification Streptomyces chemistry.chemical_compound Milbemycin chemistry Furan Side chain Fermentation
Zdroj:	ChemInform. 27
ISSN:	0931-7597
Popis:	Ten novel alpha and beta class milbemycins have been isolated and characterized from the Streptomyces sp. E225, which has previously been shown to produce four related milbemycins. Some of the metabolites contain new structural features including, VM48641 which possesses an alpha-methoxyl substituent at C-27, and VM48642 which contains a furan ring at the terminus of the C-26 side chain. Several of these new compounds were shown to possess potent anthelmintic activity. An analysis of NMR chemical shift trends in this series of metabolites is presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::769c79d111b8db22bb2bc5e5f721a9d8 https://doi.org/10.1002/chin.199635236 Zobrazit plný text záznamu Plný text