A Review of the Pathogenesis of Pediatric Asthma and the Effect of Leukotriene Modifiers in Pediatric Asthma Management
| Autor: | Haneen Jameel Alshareef, Afnan Abdullah Aljehani, Fahad Obaid Alshammari, Abdullah Abdulaziz Bin Jariyd, Muayad Mahmood Anbar Serri, Abrar Mohammed noor Gashgari, Raed Mohammad noor Alsamadani, Rayan Ibrahim Sayyal, Bayan Ali Alqarni, Ola Abdullah Al-Nemer |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Leukotriene Exacerbation business.industry medicine.drug_class Inflammation medicine.disease Pathophysiology respiratory tract diseases 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030228 respiratory system immune system diseases Immunology medicine Corticosteroid medicine.symptom Airway business Montelukast Asthma medicine.drug |
| Zdroj: | The Egyptian Journal of Hospital Medicine. 69:2378-2383 |
| ISSN: | 1687-2002 |
| Popis: | Background: Asthma is the most common chronic illness that affects children. It is described by chronic airway inflammation, remodeling of the airway wall, and airway hyper-responsiveness to non-specific spasms in response to stimuli causing a reversible airflow obstruction. Leukotrienes are one of the primary chemical mediators of inflammation in asthmatic airway, therefore leukotriene modifiers are an important class of drug for treating asthma. Methodology: We conducted this review using a comprehensive search of MEDLINE, PubMed, and EMBASE, January 1981, through February 2017. The following search terms were used: asthma pathophysiology, chemokines, leukotriene, leukotriene modifiers, Montelukast in asthma management Aim: our aim was to understand in depth the pathophysiology of pediatric asthma, and to study the effect of leukotriene modifiers in asthma management. Conclusion: For management of pediatric asthma, the leukotriene modifiers play a key role. New studies have shown that they could help in reducing dose and dependency on inhaled corticosteroid for maintenance, and decrease the need of systemic steroids in exacerbation. Leukotriene modifiers can have a positive impact on future asthma management and requires more studies to be done in this subject. |
| Databáze: | OpenAIRE |
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