Antioxidant and Hepatoprotective Effects of Rosa damascena
| Autor: | B H Babu, C R Achuthan, J Padikkala |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Pharmacology
Antioxidant biology Lipid peroxide Chemistry medicine.medical_treatment Pharmaceutical Science General Medicine biology.organism_classification law.invention Transaminase Rosa × damascena Glutamine chemistry.chemical_compound Complementary and alternative medicine Biochemistry law Drug Discovery Carbon tetrachloride medicine Molecular Medicine Hydroxyl radical Food science Phytotherapy |
| Zdroj: | Pharmaceutical Biology. 41:357-361 |
| ISSN: | 1744-5116 1388-0209 |
| DOI: | 10.1076/phbi.41.5.357.15945 |
| Popis: | The fresh juice of Rosa damascena Mill. flower exhibited promising in vitro antioxidant potential. The partially purified acetone fraction (AF) from silica gel column chromatography was found to be the active fraction with antioxidant properties. The AF required for 50% inhibition of superoxide radical production, hydroxyl radical generation and lipid peroxide formation were 13.75, 135 and 410µg/ml, respectively. Oral administration of AF at 50mg/kg body weight significantly reduced the serum alkaline phosphatase (ALP), glutamine pyruvate transaminase (GPT) and glutamine oxaloacetate transaminase (GOT) activity and lipid peroxide level in rats receiving an acute dose of CCl 4. This indicated that R. damascena could protect against CCl 4 induced hepatotoxicity, possibly by its free radical scavenging activity. |
| Databáze: | OpenAIRE |
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