Study of lipoprotein particles LpAI and LpAI:AII in patients before coronary bypass surgery

Autor:	Y Madec, J L Auget, M Coste-Burel, F Mainard, L Chivot
Rok vydání:	1990
Předmět:	Apolipoprotein AI medicine.medical_specialty business.industry Biochemistry (medical) Clinical Biochemistry Mean age Endocrinology Risk groups Bypass surgery Internal medicine Coronary vessel Medicine In patient Risk factor business hormones hormone substitutes and hormone antagonists Lipoprotein
Zdroj:	Clinical Chemistry. 36:1889-1891
ISSN:	1530-8561 0009-9147
Popis:	Lipids, apolipoproteins, and LpAI and LpAI:AII particles were studied in 43 men (mean age 51, SD 7, years) 24 h before their coronary bypass surgery and in 54 control men (mean age 46 SD 9, years). LpAI and LpAI:AII were analyzed by electroimmunodiffusion and by a noncompetitive enzyme-linked immunoassay, respectively. Concentrations of LpAI and LpAI:AII in the bypass patients were significantly lower (P less than 0.001) than those in the controls. Apolipoprotein AI was significantly correlated with LpAI (P less than 0.001) and LpAI:AII (P less than 0.01) in controls, but only with LpAI:AII (P less than 0.001) in bypass patients. Discriminant analysis between controls and patients showed apolipoprotein AI to be the most powerful discriminant factor; the addition of LpAI and LpAI:AII did not improve discriminant power. We conclude that the determination of LpAI and LpAI:AII particles reflects metabolic disorders in patients but does not significantly influence the discrimination of such patients into risk groups.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::75e83cc7f59f1afcfd0bb886eac5790b https://doi.org/10.1093/clinchem/36.11.1889 Zobrazit plný text záznamu