| Autor: |
Varghese T. George, Robert C. Elston, Chris I. Amos, Laura J. Ward, Gerald S. Berenson, D. C. Rao |
| Rok vydání: |
1987 |
| Předmět: |
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| Zdroj: |
Genetic Epidemiology. 4:267-275 |
| ISSN: |
0741-0395 |
| DOI: |
10.1002/gepi.1370040405 |
| Popis: |
A large pedigree with high prevalence of heart disease is investigated to analyse the association between polymorphic blood markers and quantitative risk factors for cardiovascular disease. The analysis incorporates a familial correlation structure among the individuals in the pedigree and a generalized power transformation to induce approximate residual normality of the risk factors. A total of 380 marker/ risk factor combinations are analysed, and at the nominal 1 % significance level, positive associations are found between the A antigen of the ABO locus and both serum total cholesterol and low-density lipoprotein cholesterol, and negative associations are found between the B antigen of the ABO locus and serum total cholesterol, and between the B allele of acid phosphatase (AP) locus and systolic blood pressure. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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