Synthesis and Pharmaco-Toxicological Characteristics of 3-Substituted 4-Hydroxy-6-Phenyl-3,4-Dihydro-2H-1,3-Oxazines

Autor:	A R Galembikova, S. S. Zykova, T. F. Odegova, Sergei Boichuk
Rok vydání:	2015
Předmět:	Pharmacology chemistry.chemical_classification Antioxidant Stereochemistry DPPH medicine.medical_treatment Pharmacology toxicology Oxazines Acute toxicity In vitro chemistry.chemical_compound chemistry Drug Discovery medicine Organic chemistry
Zdroj:	Pharmaceutical Chemistry Journal. 48:706-710
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-015-1177-0
Popis:	Reactions between 1,6-diaryl-3,4-dihydroxy-2,4-hexadiene-1,6-dione and various arylidenearylamines formed 3-substituted 4-hydroxy-6-phenyl-3,4-dihydro-2H-1,3-oxazines. The synthesized compounds were examined in vitro for antioxidant properties, cytotoxic activity, and acute toxicity. The highest antioxidant activity was observed for (2Z)-3-hydroxy-3-[(4-hydroxy-2-(4-methylphenyl)-3, 6-diphenyl-3, 4-dihydro-2H-1,3-oxazin-4-yl]-1-phenylprop-2-en-1-one (IIb) and (2Z)-3-hydroxy-[4-hydroxy-3-(4-methoxyphenyl)-2-(4-methylphenyl)-6-phenyl-3,4-dihydro-2H-1,3-oxazin-4-yl]-1-phenylprop-2-en-1-one (IIc). The synthesized compounds did not exhibit cytotoxic properties in vitro.
Databáze:	OpenAIRE
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