Acceptorless dehydrogenative construction of CN and CC bonds through catalytic aza-Wittig and Wittig reactions in the presence of an air-stable ruthenium pincer complex
| Autor: | Kalicharan Das, Bitan Sardar, Dipankar Srimani, Nandita Biswas |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Double bond 010405 organic chemistry Chemistry Aryl chemistry.chemical_element Alcohol 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences Pincer movement Ruthenium Catalysis Inorganic Chemistry chemistry.chemical_compound Wittig reaction Azide |
| Zdroj: | Dalton Transactions. 48:6501-6512 |
| ISSN: | 1477-9234 1477-9226 |
| DOI: | 10.1039/c8dt04725a |
| Popis: | The construction of C[double bond, length as m-dash]N bonds was achieved by the dehydrogenative coupling of alcohol and azide via aza-Wittig type reaction. The reaction is catalyzed by an acridine-derived ruthenium pincer complex and does not use any oxidant. The present protocol offers a wide substrate scope, including aliphatic, aryl or heteroaryl alcohol/azides. This expeditious protocol was successfully applied to construct a C[double bond, length as m-dash]C bond directly from alcohol via dehydrogenative Wittig reaction. Furthermore, the synthesis of structurally important pyrrolo[1,4]benzodiazepine derivatives was also achieved by this methodology. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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