Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity
| Autor: | Noriko Sakaida, Radek Sima, Jana Nemcova, Chisato Ohe, Naoto Kuroda, Stela Bulimbasic, Dusan Danis, Milan Hora, Michal Michal, M. Franco, Dmitry V. Kazakov, Ondřej Hes |
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| Rok vydání: | 2008 |
| Předmět: |
Pathology
medicine.medical_specialty biology Adenoma Vimentin Cell Biology General Medicine medicine.disease Clear cell papillary renal cell carcinoma Pathology and Forensic Medicine Clear cell carcinoma Keratin 7 Renal Angiomyoadenomatous Tumor medicine biology.protein Stromal tumor Molecular Biology Clear cell |
| Zdroj: | Virchows Archiv. 454:89-99 |
| ISSN: | 1432-2307 0945-6317 |
| DOI: | 10.1007/s00428-008-0697-3 |
| Popis: | We present a series of a distinct tumorous entity named renal angiomyoadenomatous tumor (RAT). Five cases were retrieved from the consultation files of the authors. Histologic and immunohistochemical features were evaluated. Sequencing analysis of coding region of the VHL gene was carried out in all cases. The tumors were composed of admixture of an epithelial clear cell component and prominent leiomyomatous stroma. Epithelial cells formed adenomatous tubular formations endowed with blister-like apical snouts. All tubular/glandular structures were lined by a fine capillary network. The epithelial component was positive for epithelial membrane antigen, CK7, CK20, AE1-AE3, CAM5.2, and vimentin in all cases. In all analyzed samples, no mutation of the VHL gene was found. RAT is a distinct morphologic entity, being different morphologically, immunohistochemically, and genetically from all renal tumors including conventional clear cell carcinoma and mixed epithelial and stromal tumor of kidney. |
| Databáze: | OpenAIRE |
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