Reflectance confocal microscopy features of mycosis fungoides and Sézary syndrome: correlation with histopathologic and T-cell receptor rearrangement studies
| Autor: | Klaus J. Busam, Silvia E. Mancebo, Eileen S. Flores, Christiane Querfeld, Patricia L. Myskowski, Anna Skripnik, Miguel Cordova, Milind Rajadhyaksha, Sarah I. Jawed |
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| Rok vydání: | 2016 |
| Předmět: |
Reflectance confocal microscopy
Mycosis fungoides medicine.medical_specialty Pathology Histology Atypical Lymphocyte business.industry T-cell receptor Dermatology Gene rearrangement medicine.disease Pathology and Forensic Medicine Correlation 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis medicine Histopathology business Kappa |
| Zdroj: | Journal of Cutaneous Pathology. 43:505-515 |
| ISSN: | 0303-6987 |
| DOI: | 10.1111/cup.12708 |
| Popis: | BACKGROUND Mycosis fungoides/Sezary syndrome (MF/SS) often requires multiple skin biopsies for definitive diagnosis. In vivo reflectance confocal microscopy (RCM) visualizes high-resolution cellular detail of the skin. The objective of this study is to evaluate the morphologic features of MF/SS using RCM and to correlate RCM features with histopathology and T-cell receptor (TCR) gene rearrangement studies. METHODS A cohort of patients with active/recurrent or suspicious MF/SS disease was prospectively recruited for RCM imaging and histopathologic/RCM images were evaluated. Statistical analyses were performed to identify unique RCM features and to correlate RCM features with histopathologic findings and TCR rearrangement studies. RESULTS Eighty-three lesions were evaluated. Correlation between RCM and histopathology was moderate for all relatable features (κ = 0.41, p |
| Databáze: | OpenAIRE |
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