Theoretical investigation for optimizing the production of 223Ra in research reactors for treatment of bone metastases
| Autor: | Kondayya Gundra, S. V. Thakare, Lakshay Jain |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Materials science
Health Toxicology and Mutagenesis Nuclear engineering Targeted radionuclide therapy Public Health Environmental and Occupational Health Solver 010403 inorganic & nuclear chemistry 01 natural sciences Pollution 0104 chemical sciences Analytical Chemistry Nuclear Energy and Engineering Research centre Yield (chemistry) Radiology Nuclear Medicine and imaging Irradiation Nuclide Neutron irradiation Spectroscopy |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry. 325:905-911 |
| ISSN: | 1588-2780 0236-5731 |
| DOI: | 10.1007/s10967-020-07159-9 |
| Popis: | 223Ra is one of the most promising $$\alpha$$ -particle emitters for targeted radionuclide therapy. In this work, the possibility of producing 223Ra by neutron irradiation of 226Ra in Dhruva Reactor at Bhabha Atomic Research Centre, India has been studied. A Bateman equation solver has been developed and used to calculate the activity yield of 227Ac for various combinations of irradiation and cooling periods. Based on this analysis, optimum time of irradiation and cooling have been estimated for maximizing the activity of 227Ac while keeping the activity from other unwanted nuclides as small as reasonably possible. |
| Databáze: | OpenAIRE |
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