Suicidal ligature strangulation without an auxiliary mechanism. Reports of two cases with a cotton rope or a T-shirt and staining results of the brains using anti HSP-70, CIRBP, RBM3, HIF1-alpha, SIRT 1 and p53 antibodies
| Autor: | Akari Takaya, Katsuji Nishi, Satoshi Furukawa, Lisa Wingenfeld, Tokiko Nakagawa, Satomu Morita, Ikuo Sakaguchi |
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| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Romanian Journal of Legal Medicine. 21:9-14 |
| ISSN: | 1844-8585 1221-8618 |
| DOI: | 10.4323/rjlm.2013.9 |
| Popis: | It is still often described in forensic textbooks that suicidal strangulation by ligature without auxiliary device to remain tightening the ligature after unconsciousness of the victim. We report two cases of suicidal ligature strangulation without auxiliary mechanism. One occurred in a closed room and other was carried out in a police cell. These two cases reveal that the suicidal ligature strangulation is possible without auxiliary mechanism, however it was difficult to distinguish from homicide only from forensic autopsy findings, although death scenes and existence of suicidal notes produced clear verdicts of suicide in two cases. The death mechanism in these cases was discussed. The nucleus of the neuronal cells showed good reactivity with hypoxia or ischemia related antibodies, such as cold inducible RNA-binding protein (CIRBP), RNA-binding motif protein 3(RBM3), heat shock protein 70(HSP-70) and hypoxia-inducible factor 1(HIF-1), however the cells showed no reactivity with anti Sirtuin 1(SIRT 1) and p53 antibodies which are related energy metabolism or apoptosis. This is the first report in which the expression of hypoxia and /or ischemic related antigens described above was confirmed even in post-mortem human brains. |
| Databáze: | OpenAIRE |
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