The Body's Response to Inadvertent Implants: Respirable Particles in Lung Tissues
| Autor: | M. Kozak, P. A. Nickerson, D. Glaves-rapp, Robert E. Baier, E. Axelson, Anne E. Meyer, Robert L. Forsberg |
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| Rok vydání: | 2000 |
| Předmět: |
Pathology
medicine.medical_specialty Lung Materials science Glass fiber Mineralogy Surfaces and Interfaces General Chemistry Prussian blue staining Lung lobe Surfaces Coatings and Films medicine.anatomical_structure Mechanics of Materials In vivo Materials Chemistry medicine Fiber degradation Fiber Respiratory system |
| Zdroj: | The Journal of Adhesion. 74:103-124 |
| ISSN: | 1545-5823 0021-8464 |
| DOI: | 10.1080/00218460008034526 |
| Popis: | Instillation of respirable glass fibers to rat lungs served as an in vivo model for the detection and evaluation of differential local biological responses to particulate matter in the deep lung. Three compositions of vitreous glass, stonewool, and refractory fiber materials (MMVF 10, HT, and RCF1a) were harvested with surrounding lung tissues and examined both histologically and by physical/chemical assays to correlate the observed differential dissolution events with specific biological responses associated with each material. Specimens at 2-days, 7-days, 30-days and 90-days post-instillation were compared from at least three rats for each condition and for phosphate-buffered-saline controls. HT fiber surface and bulk chemistry uniquely allowed direct histochemical visualization of fiber degradation steps by Prussian Blue staining, while multiple attenuated internal reflection infrared spectroscopy and energy-dispersive X-ray analysis of unfixed, fresh lung lobe slice surfaces revealed the conc... |
| Databáze: | OpenAIRE |
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