Abstract TP178: Pre-existing Volume of White Matter Disease Predicts Ischemic Stroke
| Autor: | Mahesh V Jayaraman, Shawna Cutting, Ryan A McTaggart, Karen L. Furie, Scott Collins, Derek Merck, Brian MacGrory, Tina Burton, Andrew D Chang, Shadi Yaghi, Ariana J Andere |
|---|---|
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Stroke. 50 |
| ISSN: | 1524-4628 0039-2499 |
| DOI: | 10.1161/str.50.suppl_1.tp178 |
| Popis: | Background: Patients are more likely to develop white matter disease (WMD) and microhemorrhage (MH) after ischemic stroke. Little is known about whether stroke patients had an increased prevalence of these findings before a stroke compared to patients who did not go on to develop a stroke. Methods: We retrospectively identified patients admitted to our institution with ischemic stroke between 5/16 - 12/17 who had magnetic resonance imaging (MRI) of the brain between 30 days-2 years prior to their stroke. Age and gender-matched controls for the initial MRI were identified for pair-wise comparison. Automatic segmentations of gray and white matter volumes and manual segmentation of WMD and MH (size Results: Among the 96 patients in our study, stroke patients (n=48, mean age 68, 50% female) had lower rates of cancer (p=0.03) but higher rates of hyperlipidemia (p=0.024) compared to controls. Stroke patients exhibited greater WMD volume (15.7±20.2 vs 7.3±10.4 mL, p= 0.012) compared to controls, but not MH number (p=0.29) or total MH volume (p=0.26). Although history of stroke was associated with new presentation of stroke (72.9% vs 22.9%, p Conclusion: Increased volume of white matter disease correlates with a greater risk of future ischemic stroke. These results should be validated in subsequent studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|