Automated production of carbon-11 labelled acetate to allow detection of transient myocardial ischemia in man, using positron emission tomography
| Autor: | L. Quaglia, Pierre Rigo, J.M. Peters, R. Cantineau, C. De Landsheere, G. Del Fioe, D. Raets, J. L. Piette |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
medicine.diagnostic_test
Chemistry Health Toxicology and Mutagenesis Carbonation Transient myocardial ischemia Radiochemistry Public Health Environmental and Occupational Health chemistry.chemical_element Pollution Analytical Chemistry chemistry.chemical_compound Nuclear Energy and Engineering Human use Carboxylation Positron emission tomography Carbon dioxide Magnesium bromide medicine Radiology Nuclear Medicine and imaging Carbon Spectroscopy |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry. 87:1-13 |
| ISSN: | 1588-2780 0236-5731 |
| DOI: | 10.1007/bf02204318 |
| Popis: | The synthesis of11C-acetate has been achieved via carbonation of methyl magnesium bromide with11C-labelled carbon dioxide. Using this procedure, 7.4 GBq /200 mCi/ of11CO2 produced by the14 N/P,α/11C nuclear reaction, was converted, within 20 min into11C-acetate with an activity higher than 2.22 GBq /60 mCi/. Chemical and biologic quality control shows that the product is pure, sterile, and pyrogen-free and therefore suitable for human use. Handling considerable amounts of activity has led us to automate the11C-acetate synthesis. The different parts of the system-programmable controller, sensors, automatic neutralization system-are described in detail. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink