Efficient C-7 or C-3/C-7 Direct Arylation of Tri- or Disubstituted Imidazo[1,2-b]pyrazoles

Autor:	Gérald Guillaumet, Sandrine Grosse, Christelle Pillard, Philippe Bernard
Rok vydání:	2013
Předmět:	chemistry.chemical_compound chemistry Aryl Organic Chemistry Direct coupling Pyrazole Medicinal chemistry
Zdroj:	Synlett. 24:2095-2101
ISSN:	1437-2096 0936-5214
DOI:	10.1055/s-0033-1339657
Popis:	A novel and efficient method of C-7 direct arylation of the imidazo[1,2- b ]pyrazole core, never described to date, is presented in this paper. Series of electron-rich or electron-poor aryl and heteroaryl groups were easily introduced. The corresponding products were obtained in moderate to excellent yields thanks to this ­pallado-catalyzed and microwave-assisted process. A one-pot ­double C-3 and C-7 direct coupling is also reported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::74b666b6662935b2f25e7910774d22e3 https://doi.org/10.1055/s-0033-1339657 Zobrazit plný text záznamu