Assessment of Aortic Stiffness in Marfan Syndrome Using Two-Dimensional and Doppler Echocardiography
| Autor: | James C. Moggridge, Francisco Alpendurada, George R. Sutherland, Anne H. Child, Venediktos V Kapetanakis, Samir K. Saha, Michael J. Mullen, John Camm, Bart Bijnens, Anatoli Kiotsekoglou, Malini Govindan |
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| Rok vydání: | 2011 |
| Předmět: |
musculoskeletal diseases
Aortic valve Marfan syndrome Aortic arch medicine.medical_specialty Aorta medicine.diagnostic_test business.industry Doppler echocardiography medicine.disease QRS complex medicine.anatomical_structure Internal medicine medicine.artery Descending aorta cardiovascular system Cardiology Medicine Radiology Nuclear Medicine and imaging Aortic stiffness cardiovascular diseases Cardiology and Cardiovascular Medicine business |
| Zdroj: | Echocardiography. 28:29-37 |
| ISSN: | 0742-2822 |
| DOI: | 10.1111/j.1540-8175.2010.01241.x |
| Popis: | Background: Extracellular matrix remodeling in the aortic wall results in increased aortic stiffness (AoS) in Marfan syndrome (MFS). Pulsed-wave velocity (PWV) constitutes the best indirect AoS measurement. We aimed to assess PWV in MFS patients using two-dimensional (2D) and Doppler echocardiography. Methods: Thirty-one MFS patients, (mean age 31 ± 14 years, 16 men) and 31 controls were examined. Blood flow was recorded in the aorta near the aortic valve and immediately after in the descending aorta with simultaneous electrocardiography. PWV was calculated by dividing the distance between the two sample volume positions (D) by the time difference (TD) between the intervals from the QRS start to the ascending and descending aortic flow onsets. B-stiffness was also measured. Results: TD (described in “Methods” section) and, aortic arch length were significantly increased in MFS patients, P < 0.001. Thus, PWV values were significantly higher in patients when compared with controls, 7.20 m/s (5.12, 9.43) versus 4.64 m/s (3.37, 6.24), P < 0.001. B-stiffness was also significantly increased in MFS patients; 5.15 (3.69, 7.65) versus 2.44 (1.82, 3.66), P < 0.001. Multiple regression analysis showed a positive association with MFS diagnosis and age, (P = 0.002 and 0.009, respectively). Reproducibility of PWV measurements was |
| Databáze: | OpenAIRE |
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