EVALUATION OF NEOPTERIN AS A PROGNOSTIC MARKER FOR SEVERITY OF PNEUMONIA IN PEDIATRICS
| Autor: | Mahmoud Mohamed Rabie, Amal F. Ghareeb, yousif mohamed yousf, Dina shokry |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pediatrics
medicine.medical_specialty Receiver operating characteristic business.industry Significant difference Case-control study Area under the curve Neopterin medicine.disease Pneumonia chemistry.chemical_compound chemistry immune system diseases medicine Biomarker (medicine) Cutoff point business |
| Zdroj: | Zagazig University Medical Journal. |
| ISSN: | 2357-0717 |
| DOI: | 10.21608/zumj.2019.11318.1178 |
| Popis: | Background: The aim of this study was to investigate the role of Neopterin in evaluation of severity and outcome of pneumonia in pediatric Department of Zagazig University Hospitals.Methods: A prospective case control study was carried out at the pediatric Department of Zagazig University Children Hospitals during the period from November 2017 to December 2018 .sixty infants and children patients participated in the study 40 were diagnosed as pneumonia admitted to Pediatric Department of Zagazig University as case group And twintyof control group.Results: In our study there was statistically significant difference between case and control groups in Neopterin level, there is statistically significant difference in Neopterin level between cases that need ICU dmission and M.V. and cases treated in ward only without need, there was statistically significant difference in Neopterin level between survivors and non-survivors. In this study, there was statistically significant difference in Neopterin level with disease severity.in which Neopterin is higher in severe than moderate and mild cases. Our study shows that there was statistically significant positive correlation between Neopterin level and total PRESS score, granulocytes and CRP. In our study we tried to detect the cutoff point of Neopterin to detect pneumonia calculated from ROC curves it was > 13.93 (nmol/L), and the area under the curve of Neopterin was0.866 with sensitivity 92.3% and specificity 77.8%.Conclusion: Neopterin is a useful prognostic marker for pneumonia in Pediatrics. The present study suggests that Neopterin is a promising biomarker for reflecting the severity of Pneumonia. |
| Databáze: | OpenAIRE |
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