Breast cancer and human papillomavirus (HPV) infection: No evidence of a viral etiology in a group of Swiss women
| Autor: | Andrea Forster, Hans Jörg Altermatt, Guenther Gruber, Richard H. Greiner, Katja Lindel |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Oncology
medicine.medical_specialty biology business.industry HPV infection General Medicine biology.organism_classification medicine.disease Virology law.invention chemistry.chemical_compound Breast cancer chemistry law Internal medicine medicine Surgery Human papillomavirus Papillomaviridae Breast carcinoma business DNA Viral etiology Polymerase chain reaction |
| Zdroj: | The Breast. 16:172-177 |
| ISSN: | 0960-9776 |
| Popis: | There are controversial data on the meaning of viral induction of breast cancer. The aim of this study was to investigate the presence of human papillomavirus (HPV) DNA in patients with breast carcinoma and the correlation of viral infection with disease outcome. Paraffin-embedded sections from 81 patients with breast cancer were analyzed for HPV DNA by polymerase chain reaction (PCR) using the SPF1/2 primers covering about 40 different low-, intermediate- and high-risk types. We found all samples were negative for HPV DNA. Our analysis could not support a role of HPV in breast carcinoma. Controversial published data indicate a need for further, larger epidemiologic studies. |
| Databáze: | OpenAIRE |
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