Dyslipidemia and oxidative stress are causative factors for atherosclerosis changes in hemodialysis patients
| Autor: | T. Madhusudhana Rao, D. S. S. K. Raju, B. H. V. K. Praveen Varma |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Nephrology
medicine.medical_specialty medicine.diagnostic_test business.industry medicine.medical_treatment medicine.disease medicine.disease_cause Gastroenterology Internal medicine medicine Hemodialysis Endothelial dysfunction Lipid profile business Dyslipidemia Oxidative stress Kidney disease Cause of death |
| Zdroj: | International Journal of Advances in Medicine. 6:1383 |
| ISSN: | 2349-3933 2349-3925 |
| DOI: | 10.18203/2349-3933.ijam20194141 |
| Popis: | Background: Cardiovascular disease is one of the leading cause of death in chronic kidney disease. The increased cardiovascular mortality observed in all stages of Chronic kidney disease patients. In hemodialysis cardiovascular mortality is more than 60%. In hemodialysis dyslipidemia contribute for the triggering of atherosclerosis. Endothelial dysfunction and oxidative stress are serves as main precursor for the progression of atherosclerosis. So the present study was aimed at studying lipid profile and oxidative stress in hemodialysis patients.Methods: A cross sectional study carried out over a 2 year period in Department Nephrology and General Medicine OPD, MIMS, Vizianagaram, Andhra Pradesh, India. A total of 60 hemodialysis patients are included. In all the participants Lipid profile, SOD, MDA and Serum Nitrate was measured. Results: There is a significantly increased levels of serum triglycerides and VLDL in hemodialysis patients when compared with Control. The HDL-C was significant Lower in hemodialysis patients when compared with control. The serum total cholesterol and LDL-C not shown any significant change. The Serum MDA and Serum Nitrate was significantly higher in hemodialysis patients compared with Control and it is statistically significant (p |
| Databáze: | OpenAIRE |
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