Iridium(iii )-bis(imidazolinyl)phenyl catalysts for enantioselective C–H functionalization with ethyl diazoacetate
| Autor: | Clayton P. Owens, N. Mac E Weldy, S. Chen, Cameron Herting, Zachary L. Niemeyer, Andrew G. Schafer, Simon B. Blakey, Adrián Varela-Álvarez, Huw M. L. Davies, Matthew S. Sigman, Djamaladdin G. Musaev |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Steric effects
010405 organic chemistry Intermolecular force Enantioselective synthesis chemistry.chemical_element Substrate (chemistry) General Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound Ethyl diazoacetate chemistry Organic chemistry Surface modification Iridium |
| Zdroj: | Chemical Science. 7:3142-3146 |
| ISSN: | 2041-6539 2041-6520 |
| Popis: | The intermolecular enantioselective C–H functionalization with acceptor-only metallocarbenes is reported using a new family of Ir(III)-bis(imidazolinyl)phenyl catalysts, developed based on the interplay of experimental and computational insights. The reaction is tolerant of a variety of diazoacetate precursors and is found to be heavily influenced by the steric and electronic properties of the substrate. Phthalan and dihydrofuran derivatives are functionalized in good yields and excellent enantioselectivities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|