Integracide K: A New Tetracyclic Triterpenoid fromDesmodium uncinatum(Jacq.) DC. (Fabaceae)
| Autor: | Beaudelaire Kemvoufo Ponou, Matthias F. Melzig, Kristina Jenett-Siems, Borice Tapondjou Tsafack, Raymond Ngansop Nono, Rémy Bertrand Teponno, Léon Azefack Tapondjou, Hee Juhn Park |
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| Rok vydání: | 2017 |
| Předmět: |
Ergosterol
010405 organic chemistry Chemistry Stereochemistry Organic Chemistry Isovitexin Fabaceae 01 natural sciences Mass spectrometric 0104 chemical sciences Sodium salt Desmodium uncinatum 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Triterpenoid Drug Discovery Botany Spectral data |
| Zdroj: | Natural Product Sciences. 23:113 |
| ISSN: | 2288-9027 1226-3907 |
| Popis: | A new tetracyclic triterpenoid [4,4,24-trimethylcholesta-Δ8,9;14,15;24,28-trien-3β,11β,12α-triol-12-acetate, 3-sulfate] sodium salt (1), together with eight known compounds including ergosterol 5α,8α-endoperoxide (2), 1,9-dihydroxy-3-methoxy-2-methylpterocarpan (3), 3-O-β-D-2-acetyl-amino-2-deoxyglucopyranoxyloleanoic acid (4), hydnocarpin (5), derrone (6), isovitexin (7), erythrinin C (8), and 5,4`-dihydroxy-2``-hydroxyisopropyldihydrofurano [4,5:7,8]-isoflavone (9), were isolated from the EtOAc soluble fraction of the methanol extract of aerial part of Desmodium uncinatum collected in the western highland of Cameroon. The structures of these compounds were established by comprehensive interpretation of their spectral data mainly including 1D- (1H and 13C), 2D-NMR (1H-1H COSY, HMQC, HMBC) spectroscopic and ESI-TOF-MS mass spectrometric analysis. The isolation of an integracide-like compound from plant origin is a very unusual finding. |
| Databáze: | OpenAIRE |
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