OREOCALLIS GRANDIFLORA PHOTOPROTECTIVE EFFECT AGAINST ULTRAVIOLET B RADIATION-INDUCED CELL DEATH
| Autor: | Diego Vinueza, Karen Acosta, Cajamarca D, Gisela Pilco |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pharmacology
Residue (complex analysis) Programmed cell death Ethanol Strain (chemistry) Pharmaceutical Science Rotary evaporator medicine.disease_cause 03 medical and health sciences Freeze-drying chemistry.chemical_compound 0302 clinical medicine Ultraviolet B radiation chemistry 030220 oncology & carcinogenesis medicine Pharmacology (medical) Food science Escherichia coli 030217 neurology & neurosurgery |
| Zdroj: | Asian Journal of Pharmaceutical and Clinical Research. 11:276 |
| ISSN: | 2455-3891 0974-2441 |
| DOI: | 10.22159/ajpcr.2018.v11i2.20910 |
| Popis: | Objective: The aim of this research was to evaluate the photoprotective effect of Oreocallis grandiflora hydroalcoholic extract (OGHE) againstultraviolet (UV)B-induced cell death model on a strain of Escherichia coli (ATCC 25922) and to determine the sun protection factor (SPF) using theequation proposed by Mansur.Methods: OGHE was obtained from leaves of O. grandiflora, following a standardized methodology. In short, O. grandiflora leaves were extracted withethanol 70% v/v and defatted with n-hexane, hydroalcoholic fraction was concentrated under controlled conditions through rotary evaporator, andfinally, the residue was freeze drying to obtain OGHE. The photoprotective effect was carried out using in vitro UVB-induced cell death model on astrain of E. coli (ATCC 25922), like a first approach to study its potential application on cosmetics.Results and Conclusions: From results, O. grandiflora is an important resource to produce new cosmetic products. However, the safety of OGHE isnecessary to a rational development in that sense. OGHE shows advantages in relation to conventional active compounds of commercial sunscreens usedin this research (2-ethylhexyl 4-methoxycinnamate and 2-ethylhexyl 4-(dimethylamino)benzoate) at the concentration of 2 mg/mL, on survivor time(with OGHE until 120 min), range of inactivation of E. coli caused by UVB (OGHE K value minor against to positive controls), and high SPF (13.56±0.21). |
| Databáze: | OpenAIRE |
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