Isolation and structure of the unusual Indian Ocean Cephalodiscusgilchristi components, cephalostatins 5 and 6
Autor: | Jean M. Schmidt, Nigel D. Christie, Dennis L. Doubek, George R. Pettit, Masuo Inoue, Claude Dufresne, Yoshiaki Kamano |
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Rok vydání: | 1989 |
Předmět: | |
Zdroj: | Canadian Journal of Chemistry. 67:1509-1513 |
ISSN: | 1480-3291 0008-4042 |
Popis: | The Indian Ocean (South African) marine worm Cephalodiscusgilchristi (Hemichordata phylum) has been found to contain a series of unusual disteroidal alkaloids, designated the cephalostatins, that possess exceptionally potent lymphocytic leukemia (murine P388) cell line inhibitory activity (to ED50 10−9 μg/mL). Two of the less prominent members with P388 ED50 10−3–10−2 μg/mL, cephalostatins 5 (2) and 6 (3), were isolated and assigned structures based on rigorous interpretation of two-dimensional 400-MHz 1H and 13C nuclear magnetic resonance. Keywords: cephalostatins 5 and 6, disteroidal alkaloids, lymphocytic leukemia, cytostatic, Cephalodiscusgilchristi. |
Databáze: | OpenAIRE |
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