Recent developments in protein kinase C inhibitors

Autor:	Sandra E. Wilkinson, W. Harris, J.S. Nixon
Rok vydání:	1997
Předmět:	Pharmacology Serine/threonine-specific protein kinase General Medicine Biology Mitogen-activated protein kinase kinase MAP2K7 Cell biology Biochemistry Drug Discovery ASK1 c-Raf Casein kinase 2 Protein kinase A Protein kinase C
Zdroj:	Expert Opinion on Therapeutic Patents. 7:63-68
ISSN:	1744-7674 1354-3776
Popis:	The serine/threonine protein kinase isoenzyme family, protein kinase C (PKC), is a group of closely-related enzymes which apparently mediate a range of responses in different cell types. Their involvement in cellular proliferation and differentiation has made inhibitors of these isoenzymes of great interest as potential anticancer agents. This review looks at compounds under investigation by a number of different pharmaceutical companies within the last two years and reports on their effectiveness in models of cell proliferation and multidrug-resistance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::72aea1e5fec2d1cb7b7a9827937211b6 https://doi.org/10.1517/13543776.7.1.63 Zobrazit plný text záznamu