Risk of Lymphoma Associated with Anti-TNF Therapy in Patients with Inflammatory Bowel Disease: Implications for Therapy
| Autor: | Kofi Clarke, Michelle Rosario, Jessica Dahmus |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Crohn's disease Thiopurine methyltransferase biology Hepatosplenic T-cell lymphoma business.industry Gastroenterology Cancer medicine.disease Malignancy Inflammatory bowel disease Ulcerative colitis Lymphoma 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine medicine biology.protein 030211 gastroenterology & hepatology business |
| Zdroj: | Clinical and Experimental Gastroenterology. 13:339-350 |
| ISSN: | 1178-7023 |
| DOI: | 10.2147/ceg.s237646 |
| Popis: | Anti-tumor necrosis factor alpha (ATA) therapy plays a significant role in the treatment of moderate to severe inflammatory bowel disease (IBD). There are concerns regarding risks associated with their use, including malignancy and, specifically, lymphoma. Many previous studies have sought to determine whether there is a true link between ATA therapy in IBD and development of lymphoma. However they have been hindered by short follow-up times, few cases, and confounding factors such as previous thiopurine exposure. This review seeks to update the literature by evaluating more recent studies assessing the link between ATA monotherapy and lymphoma development. It also summarizes findings of those studies and provides additional clinical guidance pertaining to this class of biologic therapy. |
| Databáze: | OpenAIRE |
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