Trichocadinins B–G: Antimicrobial Cadinane Sesquiterpenes from Trichoderma virens QA-8, an Endophytic Fungus Obtained from the Medicinal Plant Artemisia argyi
| Autor: | Xing-Wang Zhou, Xiao-Shan Shi, Dun-Jia Wang, Ling-Hong Meng, Xiaoming Li, Hong-Lei Li, Bin-Gui Wang, Xin Li |
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| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
Antifungal Artemisia argyi Traditional medicine 010405 organic chemistry medicine.drug_class Organic Chemistry Trichoderma virens Pharmaceutical Science Endophytic fungus Sesquiterpene Antimicrobial 01 natural sciences Mass spectrometric 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Complementary and alternative medicine chemistry Drug Discovery medicine Molecular Medicine |
| Zdroj: | Journal of Natural Products. 82:2470-2476 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.9b00139 |
| Popis: | Trichocadinins B-G (1-6), six new cadinane-type sesquiterpene derivatives, each with C-14 carboxyl functionality, were isolated from the culture extract of Trichoderma virens QA-8, an endophytic fungus obtained from the fresh inner tissue of the medicinal plant Artemisia argyi. Their structures were elucidated by interpretation of the NMR spectroscopic and mass spectrometric data. The structures and absolute configurations of compounds 1 and 3 were confirmed by X-ray crystallographic analysis. Compounds 1-3 showed antibacterial and antifungal activity. |
| Databáze: | OpenAIRE |
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