A diastereospecific, non-racemic synthesis of a novel β-hydroxy-δ-lactone HMG-CoA reductase inhibitor

Autor:	Ralph P. Volante, Edward G. Corley, T.M.H. Liu, Meyer Sletzinger, James M. McNamara, Thomas R. Verhoeven
Rok vydání:	1985
Předmět:	chemistry.chemical_classification Ketone biology Stereochemistry Organic Chemistry Synthon Biochemistry Stereospecificity chemistry Enzyme inhibitor Drug Discovery HMG-CoA reductase biology.protein Lactone δ lactone
Zdroj:	Tetrahedron Letters. 26:2951-2954
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)98589-7
Popis:	The coupling of acyl anion equivalent 12b with chiral synthon 14 , derived from isoascorbic acid, and a highly stereospecific reduction of the resulting β-hydroxy ketone 3 highlight an efficient synthesis of β-hydroxy-δ-lactone 2 .
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7263f2aec9fb3887909e74d38a8f814b https://doi.org/10.1016/s0040-4039(00)98589-7 Zobrazit plný text záznamu