Genetic characterization of MHC class II DQB exon 2 variants in gayal (Bos frontalis)

Autor:	Yongke Sun, Yuai Yang, Guozhi Li, Dongmei Xi, Yuhan Chen, Tiantian Hao
Rok vydání:	2014
Předmět:	chemistry.chemical_classification Genetics MHC class II Biology biology.organism_classification Major histocompatibility complex Balancing selection Amino acid Exon chemistry biology.protein Nucleotide Gayal Gene Biotechnology
Zdroj:	Biotechnology & Biotechnological Equipment. 28:827-833
ISSN:	1314-3530 1310-2818
DOI:	10.1080/13102818.2014.960787
Popis:	In the present study, exon 2 of major histocompatibility complex (MHC) class II DQB gene from 39 gayals (Bos frontalis) was isolated, characterized and compared with previously reported patterns for other bovidae. It was revealed by sequence analyses that there are 36 DQB exon 2 variants among 39 gayals. These variants exhibited a high degree of nucleotide and amino acid substitutions with most amino acid variations occurring at positions forming the peptide-binding sites (PBS). The DQB loci were analysed for patterns of synonymous (dS) and non-synonymous (dN) substitution. The gayals were observed to be under strong balancing selection in the DQB exon 2 PBS (dN = 0.094, P = 0.001). It appears that this variability among gayals could confer the ability to mount immune responses to a wide variety of peptides or pathogens.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::722a6fbbfff0dfb1ccd76df00293643e https://doi.org/10.1080/13102818.2014.960787 Zobrazit plný text záznamu