Factors associated to resistant depression
| Autor: | J. Zohar, Stuart Montgomery, U. Bailler, P. Oswald, Daniel Souery, Joseph Bollen, Isabelle Massat, Koen Demyttenaere, Siegfried Kasper, Yves Lecrubier, Alessandro Serretti, Julien Mendlewicz |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Comorbid anxiety business.industry Proportional hazards model medicine.disease Comorbidity Psychiatry and Mental health Internal medicine Medicine Anxiety Antidepressant medicine.symptom Age of onset business Treatment-resistant depression Depression (differential diagnoses) |
| Zdroj: | European Psychiatry. 22:S69 |
| ISSN: | 0924-9338 |
| DOI: | 10.1016/j.eurpsy.2007.01.265 |
| Popis: | Background and AimsFew studies have been conducted looking at clinical features associated to treatment resistant depression (TRD) defined as failure to at least two consecutive antidepressant trials. The objective of this study was to identify clinical and demographic factors associated to TRD in a large sample of depressed patients who failed to reach response or remission after at least two consecutive adequate treatments.MethodsA total of 702 patients with unipolar major depression were included in the analysis. 346 patients were considered as non resistant. The remaining 356 patients were considered as resistant with a HAM-D-17 score remaining ≥ 17 after 2 consecutive adequate trials. Cox regression models were used to examine the association between individual clinical variables and TRD.ResultsEleven variables were found to be associated with TRD. Anxiety comorbidity (p 1 (p |
| Databáze: | OpenAIRE |
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