In vitro cytotoxicity of carbazole derivatives IV. 5,11-Dimethyl-6H-pyrido[3,2-b]carbazoles substituted on the pyridine ring

Autor:	T. Tabka, V Moinet-Hedin, Sylvain Rault, Max Robba, Pascal Gauduchon, Jean Charles Lancelot, B. Letois, J. Y. Le Talaer
Rok vydání:	1993
Předmět:	Pharmacology Carbazole Stereochemistry Organic Chemistry In vitro cytotoxicity General Medicine Ring (chemistry) Leukemia L1210 In vitro Ellipticine chemistry.chemical_compound chemistry Drug Discovery Pyridine Cytotoxicity
Zdroj:	European Journal of Medicinal Chemistry. 28:721-726
ISSN:	0223-5234
DOI:	10.1016/0223-5234(93)90032-a
Popis:	A series of 5,11-dimethyl-6H-pyrido[3,2-b]carbazoles, structurally related to the antitumor drug ellipticine, were synthesized from 3-amino-1,4-dimethyl-9H-carbazole. Among 17 derivatives, bearing various substituents on the pyridine ring, and preliminarily evaluated for cytotoxicity on L1210-cultured cells, 13 (76%) were found to be active. One of them, 5,11-dimethyl-4-ethoxy-6H-pyrido[3,2-b]carbazole, although non-substituted on C-9, displayed an activity similar to that of 9-hydroxy-N-2-methylellipticinium acetate. Structure-activity relationships have been described in detail.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::720bbcefbaa4f8c093915de2324eb802 https://doi.org/10.1016/0223-5234(93)90032-a Zobrazit plný text záznamu