Declines in highly active antiretroviral therapy initiation at CD4 cell counts ≤ 200 cells/μL and the contribution of diagnosis of HIV at CD4 cell counts ≤ 200 cells/μL in British Columbia, Canada

Autor:	Rolando Barrios, W. Chau, Adriana Nohpal, S. Kesselring, Viviane D. Lima, Hasina Samji, Lillian Lourenço, Robert S. Hogg, David M. Moore, Katherine J. Lepik, G. Colley, J. S. G. Montaner
Rok vydání:	2015
Předmět:	medicine.medical_specialty business.industry Health Policy Human immunodeficiency virus (HIV) Retrospective cohort study medicine.disease_cause Antiretroviral therapy 3. Good health Late presentation Infectious Diseases ANTIRETROVIRAL AGENTS Internal medicine Immunology medicine Pharmacology (medical) Young adult Cd4 cell count business Late initiation
Zdroj:	HIV Medicine. 16:337-345
ISSN:	1464-2662
DOI:	10.1111/hiv.12212
Popis:	Objectives The aim of the study was to examine trends in initiating highly active antiretroviral therapy (HAART) with a CD4 count ≤ 200 cells/μL and the contribution of having a CD4 count ≤ 200 cells/μL at the time of diagnosis to these trends, in British Columbia (BC), Canada. Methods We included in the analysis treatment-naive BC residents aged ≥ 19 years who initiated HAART from 2003 to 2012. Participants were classified as follows: Group 1: diagnosed and initiated HAART with a CD4 count > 200 cells/μL; Group 2: diagnosed with a CD4 count > 200 cells/μL and initiated HAART with a CD4 count ≤ 200 cells/μL; and Group 3: diagnosed and initiated HAART with a CD4 count ≤ 200 cells/μL. We measured trends in initiating HAART with a CD4 count ≤ 200 cells/μL and used logistic regression models to measure factors associated with initiating HAART with a CD4 count ≤ 200 cells/μL, stratified by having a CD4 count ≤ 200 cells/μL or > 200 cells/μL at the time of diagnosis. Results Between 2003 and 2012, 3506 BC residents initiated HAART. Of these, 44% (1558 of 3506) initiated HAART with a CD4 count ≤ 200 cells/μL. This proportion declined from 69% (198 of 287) in 2003 to 21% (81 of 330) in 2012 (P
Databáze:	OpenAIRE
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