em In vitro em drug interactions of gallates with antibiotics in em Staphylococcus Aureus em
| Autor: | Meena Kishore Sakharkar, Win Mar Soe, Chu Sing Lim L, Tzer Pin Lin R, Kishore R. Sakharkar |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
General Immunology and Microbiology
Chemistry Tetracycline medicine.drug_class Fusidic acid Antibiotics Ethyl gallate Mupirocin medicine.disease_cause Antimicrobial General Biochemistry Genetics and Molecular Biology Microbiology chemistry.chemical_compound Epicatechin gallate Staphylococcus aureus medicine lipids (amino acids peptides and proteins) medicine.drug |
| Zdroj: | Frontiers in Bioscience. :668-672 |
| ISSN: | 1945-0508 1945-0494 |
| DOI: | 10.2741/e126 |
| Popis: | The antimicrobial activities of tetracycline, mupirocin, and fusidic acid are tested in combination with Epicatechin Gallate (ECG), and Ethyl Gallate (EG) using 2 Methicillin resistant (MRSA) and 2 Methicillin sensitive (MSSA) strains of Staphylococcus aureus. Sub-inhibitory concentration of EG at 256 mg l-1 is found to be synergistic when used in combination with tetracycline, mupirocin, and fusidic acid; and a sub-inhibitory concentration of ECG at 32 mg l-1 is found to be synergistic with tetracycline in all the four Staphylococcus aureus strains tested. The synergistic combinations reduce the MICs of all the above three antibiotics by 4 fold. Combining ECG at 32 mg l-1 with mupirocin, reduces the MIC of mupirocin by four fold in MSSA C1 strain. 74 per cent of the combinations show consistent results in both time-kill assay and checkerboard method. The identified combinations may lead towards novel therapeutic interventions for treating MRSA infections. |
| Databáze: | OpenAIRE |
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