Role of Wnt/β-catenin and RANKL/OPG in bone healing of diabetic Charcot arthropathy patients
| Autor: | Jesper Fowelin, Agnetha Folestad, Susanne Asteberg, Martin Ålund, Jean Cassuto, Jan Göthlin, Ylva Aurell |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty biology business.industry Wnt signaling pathway General Medicine Bone healing medicine.disease Bone remodeling chemistry.chemical_compound Endocrinology chemistry Osteoprotegerin RANKL Internal medicine Catenin Arthropathy biology.protein Medicine Sclerostin Orthopedics and Sports Medicine Surgery business |
| Zdroj: | Acta Orthopaedica. 86:415-425 |
| ISSN: | 1745-3682 1745-3674 |
| DOI: | 10.3109/17453674.2015.1033606 |
| Popis: | Background and purpose — Charcot neuropathy is characterized by bone destruction in a foot leading to deformity, instability, and risk of amputation. Little is known about the pathogenic mechanisms. We hypothesized that the bone-regulating Wnt/β-catenin and RANKL/OPG pathways have a role in Charcot arthropathy.Patients and methods — 24 consecutive Charcot patients were treated by off-loading, and monitored for 2 years by repeated foot radiography, MRI, and circulating levels of sclerostin, dickkopf-1, Wnt inhibitory factor-1, Wnt ligand-1, OPG, and RANKL. 20 neuropathic diabetic controls and 20 healthy controls served as the reference.Results — Levels of sclerostin, Dkk-1 and Wnt-1, but not of Wif-1, were significantly lower in Charcot patients than in the diabetic controls at inclusion. Dkk-1 and Wnt-1 levels responded to off-loading by increasing. Sclerostin levels were significantly higher in the diabetic controls than in the other groups whereas Wif-1 levels were significantly higher in the healthy co... |
| Databáze: | OpenAIRE |
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