An early diagnostic tool for diabetic neuropathy: Conduction velocity distribution
| Autor: | Seckin Tuncer, Mustafa Cihat Avunduk, Nizamettin Dalkilic, Hacı Hasan Esen |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Diabetic neuropathy Physiology business.industry Population Metabolic disorder Urology medicine.disease Streptozotocin Nerve conduction velocity Compound muscle action potential Cellular and Molecular Neuroscience Endocrinology Physiology (medical) Internal medicine Diabetes mellitus medicine Neurology (clinical) Sciatic nerve education business medicine.drug |
| Zdroj: | Muscle & Nerve. 43:237-244 |
| ISSN: | 0148-639X |
| Popis: | Diabetes is a metabolic disorder that affects much of the human population. As a secondary complication, diabetic neuropathy causes time-dependent damage to peripheral nerves. In this study, experimental diabetes was induced by streptozotocin (STZ; 50 mg/kg intraperitoneally) in rats. Diabetic animals were grouped into those with 2 or 4 weeks of diabetes, whereas a control group received only the STZ vehicle (0.1 M citrate). Sciatic nerves were dissected, and compound action potentials (CAPs) were recorded. Results deduced by conventional calculation carried less information when compared with conduction velocity distribution (CVD) obtained by a computer-based mathematical model. Using the conventional approach, statistically significant changes were first seen in the fourth week of diabetes, whereas results deduced by CVD measurement could be seen in the second week. Consequently, the CVD calculation provides more information for the early diagnosis of neuropathies compared with classical conduction velocity measurements. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text