Dual Acid-Responsive Micelle-Forming Anticancer Polymers as New Anticancer Therapeutics
| Autor: | Dongwon Lee, Yerang Kim, Gilson Khang, Byungkuk Kim, Sanga Park, Eun-Sun Lee |
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| Rok vydání: | 2013 |
| Předmět: |
Materials science
Stereochemistry Prodrug Condensed Matter Physics Combinatorial chemistry Micelle In vitro Cinnamaldehyde Electronic Optical and Magnetic Materials Biomaterials chemistry.chemical_compound chemistry In vivo Drug delivery Electrochemistry medicine Ethylene glycol Camptothecin medicine.drug |
| Zdroj: | Advanced Functional Materials. 23:5091-5097 |
| ISSN: | 1616-301X |
| DOI: | 10.1002/adfm201300871 |
| Popis: | Cinnamaldehyde, a major active compound of cinnamon, is known to induce apoptotic cell death in numerous human cancer cells. Here, dual acid-responsive polymeric micelle-forming cinnamaldehyde prodrugs, poly[(3-phenylprop-2-ene-1,1-diyl)bis(oxy)bis(ethane-2,1-diyl)diacrylate]-co-4,4’(trimethylene dipiperidine)-co-poly(ethylene glycol), termed PCAE copolymers, are reported. PCAE is designed to incorporate cinnamaldehyde via acid-cleavable acetal linkages in its pH-sensitive hydrophobic backbone and self assemble to form stable micelles which can encapsulate camptothecin (CPT). PCAE self assembles to form micelles which release CPT and cinnamaldehyde in pH-dependent manners. PCAE micelles induce apoptotic cell death through the generation of intracellular reactive oxygen species (ROS) and exert synergistic anticancer effects with a payload of CPT in vitro and in vivo model of SW620 human colon tumor-bearing mice. It is anticipated that dual acid-sensitive micelle-forming PCAE with intrinsic anticancer activities has enormous potential as novel anticancer therapeutics. |
| Databáze: | OpenAIRE |
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