| Autor: | Milyakova Mn, Sarbaeva Nn, Shabanov Vv |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
chemistry.chemical_classification
biology Allopurinol General Medicine Pharmacology medicine.disease General Biochemistry Genetics and Molecular Biology Superoxide dismutase Pathogenesis chemistry.chemical_compound Enzyme Biochemistry chemistry medicine biology.protein Acute pancreatitis Pancreatitis Xanthine oxidase medicine.drug Free-radical theory of aging |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 134:26-27 |
| ISSN: | 0007-4888 |
| DOI: | 10.1023/a:1020644302486 |
| Popis: | In dogs with acute reflux pancreatitis specific activity of superoxide dismutase in the pancreas rapidly increased (over 15 min). Activation of this enzyme by free oxygen radicals was demonstrated in in vitro experiments. Treatment with allopurinol prevented activation of superoxide dismutase. Our results indicate that superoxide ions are generated in the pancreas at the early stage of acute reflux pancreatitis due to activation of xanthine oxidase. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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