Synthesis and pharmacological evaluation of tyramine congeners containing fused heterocyclic rings

Autor:	G Norcini, G Miragoli, F Santangelo, C Casagrande, G. Bertolini, L. Allievi, C Semeraro
Rok vydání:	1993
Předmět:	Pharmacology Inotrope Bicyclic molecule Chemistry Stereochemistry Organic Chemistry Vasodilation General Medicine Tyramine In vitro Guinea pig chemistry.chemical_compound Dopamine receptor Drug Discovery Phosphodiesterase III Inhibitors
Zdroj:	European Journal of Medicinal Chemistry. 28:505-511
ISSN:	0223-5234
DOI:	10.1016/0223-5234(93)90018-a
Popis:	A series of tyramine congeners carrying a fused heterocyclic ring were synthesized with the aim of combining the positive inotropic effect of the cardiac phosphodiesterase III inhibitors with the vasodilatory effect of heterocyclic dopamine receptor agonists. None of the compounds showed the desired combination of properties. 2-Ethoxycarbonyl-4-(2-aminoethyl)-7-hydroxyindole 24 elicited a marked hypotensive effect in spontaneously hypertensive rats.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::70a1cc0479540a7d8a2391015faa5db5 https://doi.org/10.1016/0223-5234(93)90018-a Zobrazit plný text záznamu