| Autor: |
Piera Viero, T Barbui, Giorgio Lambertenghi-Deliliers, Giorgio Rossi, T. Lerede, Michele Vespignani, P. Fabris, S. Morandi, Enrico Pogliani, E. Di Bona, Renato Bassan, Alessandro Rambaldi, Gianmarco Corneo, Teodosio Izzi |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
Transplantation in Hematology and Oncology ISBN: 9783642640414 |
| DOI: |
10.1007/978-3-642-59592-9_25 |
| Popis: |
We analyzed the long-term results of a phase II trial closed in 1993, including ABMT (autologous bone marrow transplant) with post-graft chemotherapy as consolidation therapy for first remission adult ALL patients. Seventy-nine patients in remission after ‘IVAP’ (idarubicin-vincristine-L-asparaginase-prednisone) were to receive 4 consolidation cycles followed by marrow harvest (unpurged), cranial irradiation, and ABMT after BCNU 300 mg/m2, etoposide 900 mg/m2, and melphalan 110 mg/m2 (restricted to patients 15–50 years-old). The ABMT regime was intentionally of „limited“ intensity, to minimize the risks of toxic death and to resume promptly continuation therapy with alternate drug pairs for 12 weeks and low-dose maintenance with mercaptopurine and methotrexate for 6 mos. (ABMT) or 18 mos. (no ABMT). At the end of early consolidation 67 patients were alive and still in CR: 10 underwent an allogeneic BMT, 32/47 aged 50 years had chemotherapy without transplants. Long-term disease-free survival was positively affected by the following variables: age |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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